教师风采

沙珍霞

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  • 发布时间:2016-07-04
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个人简介:

沙珍霞,教授,博士生导师。beat365手机官方网站水生生物学科负责人。1997年、2006年毕业于中国海洋大学beat365亚洲版官网海洋生物学专业,分获硕士、博士学位。19977月至20165月在中国水产科学研究院黄海水产研究所工作,历任助理研究员、副研究员和研究员,研究室副主任、研究室主任,先后获青岛市创先争优优秀共产党员、中国水产科学院先进工作者、中国科学研究院黄海水产研究所优秀共产党员、先进工作者、文明职工等荣誉称号。20069-20083月于美国Auburn大学博士后及访问学者。20165月作为引进人才进入beat365亚洲版官网工作,20178月被聘为beat365手机官方网站三层次特聘教授。现为国家海洋科学与技术国家试点实验室海洋渔业科学与食物产出功能实验室固定人员,中国水产学会生物技术分会专业技术委员会委员,中国海洋学会生物工程分会副秘书长,青岛市微藻产业学会、青岛市生物工程学会常务理事。

主持国家级课题9项,省市地方课题及横向课题9项,参加国家自然基金重点项目、863高技术计划、973项目及农业部行业专项等国家级课题4项,先后国内外学术刊物上发表和接收的科研论文80多篇,被SCI收录论文50多篇。授权国家发明专利7项,获得省部级及水科院科技成果奖励12项。

获青岛市第六届青年科技奖、中国水产科学研究院首届中青年拔尖人才、第五届青岛市南区专业技术拔尖人才、2017年度崂山区拔尖等学术荣誉称号。

研究方向:

海洋鱼类细胞生物学及免疫学

水生生物资源利用及生物技术

主持的国家级科研项目:

1.     国家重点研发计划子课题-“海水鱼类抗病与抗逆性状形成的分子机理(2018YFD0900301-3)” 2018.12-2022.12

2.     国家自然科学基金面上项目-“半滑舌鳎补体信号通路及抗菌免疫防御机理(31572644)”2016.01-2019.12

3.     国家自然科学基金面上项目-“半滑舌鳎miRNA表达谱构建及免疫相关性分析(31172439)”2012.01-2015.12”

4.     863高技术计划子课题-“海水养殖生物重要功能基因的发掘与研究(2012AA10A401-4)”2012.01-2015.12

5.     国家自然科学基金面上项目-“斑点叉尾鮰天然免疫基因NLRAPR基因定位及抗病机制的研究(30871941)”2009.01-2011.12

6.     863高技术计划子课题-“重要海水养殖动物细胞工程育种技术 (2006AA10A401)”2006.01-2010.12

7.     863高技术计划课题-“重要海水养殖动物细胞培养技术与细胞系建立 (2006AA09Z406)”2006.01-2009.12

8.     863高技术计划课题-“花鲈胚胎干细胞培养及基因打靶技术研究(2004AA6261102004AA629180)”2002.01-2004.102004.10-2005.10

代表性论文:

1)      Yang G, Xiu YJ, Chen YD, Bai L, Sha ZX. Identification and expression of complement component C8α, C8β and C8γ gene in half-smooth tongue sole (Cynoglossus semilaevis) and C8α recombinant protein antibacterial activity analysis. Fish and Shellfish Immunology, 2018, 72:658-669. SCI一区

2)      Sha ZX, Wang LQ, Sun LM, Chen YD, Zheng Y, Xin M, Li C, Chen SL. Isolation and characterization of monocyte/macrophage from peripheral blood of half smooth tongue sole (Cynoglossus semilaevis). Fish & Shellfish Immunology, 2017, 65: 256-266. SCI一区

3)      Wu SM, Zheng RK, Sha ZX and Sun CM. Genome Sequence of Pseudomonas stutzeri 273 and Identification of the Exopolysaccharide EPS273 Biosynthesis Locus. Mar. Drugs, 2017, 15, 218; doi:10.3390/md15070218. SCI二区

4)      Chen YD, Xia YT, Shao CW, Han L, Chen XJ, Yu MJ, Sha ZX.  Discovery and identification of candidate sex-related genes based on transcriptome sequencing of Russian sturgeons (Acipenser gueldenstaedtii) gonads. Physiological genomics, 2016, 48(7), 464-476.

5)      Yan H, Chen YD, Zhou S, Li C, Gong GY, Chen XJ, Wang TZ, Chen SL, Sha ZX. Expression profile analysis of miR-221 and miR-222 in different tissues and head-kidney cells of Cynoglossus semilaevis, following pathogen infection. Marine Biotechnology, 2016, 18:37-48. SCI一区

6)      Zheng Y, Wang N, Sha ZX, Chen SL. Establishment of a continuous cell line from female half-smooth tongue sole (Cynoglossus semilaevis). Aquaculture Research, 2016, 47(11):3608-3615.

7)      Gong GY, Sha ZX, Chen SL Li C, Yan H., Chen YD., Wang TZ. Expression Profiling Analysis of the microRNA Response of Cynoglossus semilaevis to Vibrio anguillarum and Other Stimuli. Marine Biotechnology, 2015, 17(3): 338-52. SCI一区

8)      Xiang J, Li X, Chen Y, Lu Y, Yu MJ, Chen XJ, Zhang WT, Zeng Y, Sun LM, Chen SL, Sha ZX. Complement factor I from flatfish half-smooth tongue (Cynoglossus semilaevis) exhibited anti-microbial activities. Developmental & Comparative Immunology, 2015, 53(1): 199-209. SCI一区

9)      Zeng Y, Xiang JS, Lu Y, Chen YD, Wang TZ, Gong GY, Wang L, Li XH, Chen SL, Sha, ZX. sghC1q, a novel C1q family member from half-smooth tongue sole (Cynoglossus semilaevis): Identification, expression and analysis of antibacterial and antiviral activities. Developmental and Comparative Immunology, 2015, 48, 151-163. SCI一区

10)   Zhang X, Wang S, Chen SL, Chen Y, Liu Y, Shao CW, Wang Q, Lu Y, Gong GY, Ding SX, Sha ZX. Transcriptome analysis revealed changes of multiple genes involved in immunity in Cynoglossus semilaevis during Vibrio anguillarum infection. Fish & Shellfish Immunology, 2015, 43(1):209-218. SCI一区

11)   Sha ZX, Gong GY, Wang SL, Lu Y, Wang L, Wang QL, Chen SL.  Identification and characterization of Cynoglossus semilaevis microRNA response to Vibrio anguillarum infection through high-throughput sequencing. Developmental and Comparative Immunology, 2014, 44(1):59-69. SCI一区

12)   Lu Y, Wang QL, Liu Y, Shao CW, Chen SL, Sha ZX. Gene cloning and expression analysis of IRF1 in half-smooth tongue sole (Cynoglossus semilaevis). Molecular biology reports, 2014, 41(6): 4093-4101.

13)   Li M, Wang QL, Lu Y, Chen SL, Sha ZX. Expression of NODs in channel catsh (Ictalurus punctatus) after infection with virulent Edwardsiella tarda, Aeromonas hydrophila, Streptococcus iniae and channel catfish hemorrhage reovirus. Fish & Shellfish Immunology, 2012, 33(4):1033-41. SCI一区

14)   Li M, Liu Y, Wang QL, Chen SL, Sha ZX. BIRC7 gene in channel catfish (Ictalurus punctatus): identification and expression analysis in response to Edwardsiella tarda, Streptococcus iniae and channel catfish Hemorrhage Revirus. Fish & Shellfish Immunology, 2012, 33(1):146-53. SCI一区

15)   Sha ZX, Wang QL, Liu Y, Chen SL. Identification and expression analysis of goose-type lysozyme in half-smooth tongue sole (Cynoglossus semilaevis). Fish & Shellfish Immunology, 2012, 32(1):914-921. SCI一区

16)   Sha ZX, Liu H, Wang QL, Liu Y, Lu Y, Li M, Chen SL. Channel catfish (Ictalurus punctatus) protein disulphide isomerase, PDIA6: Molecular characterization and expression regulated by bacteria and virus inoculation. Fish & Shellfish Immunology, 2012, 33(2):220-228. SCI一区

17)   Liu Y, Meng YQ, Wang QL, Sha ZX. Class II, major histocompatibility complex, transactivator (CIITA) in channel catfish: Identification and expression patterns responding to different pathogens. Molecular Biology Reports, 2012, 39(12):11041-50.

18)   Zheng Y, Wang N, Xie MS, Sha ZX, Chen SL. Establishment and characterization of a new fish cell line from head kidney of half-smooth tongue sole (Cynoglossus semilaevis). Fish Physiology and Biochemistry, 2012. 38(6): 1635-1643.

19)   Sha ZX, Luo XH, Liao XL, Wang SL, Wang QL, Chen SL. 2011. Development and characterization of 60 novel EST-SSR markers in half-smooth tongue sole (Cynoglossus semilaevis). Journal of Fish Biology. 78: 322-331.

20)   Sha ZX, Wang SL, Zhuang ZM, Wang Q, Wang Q, Li P, Ding H, Wang N, Liu ZJ, Chen SL. 2010. Generation and analysis of 10,000 ESTs from the half smooth tongue sole, Cynoglossus semilaevis Gunther and identification of microsatellite and SNP markers. Journal of Fish Biology. 76: 1190-1204.

21)   Sha ZX, Ren GC, Wang XL, Wang N, Chen SL. 2010. Development and characterization of a cell line from the embryos of half smooth tongue sole (Cynoglossus semilaevis). Acta Oceanologica Sinica. 29(2):81-87.

22)   Sha ZX, Abernathy JW, Wang SL, Li P, Kucuktas H, Liu H, Peatman E, Liu ZJ. 2009. NOD-like subfamily of the nucleotide-binding domain and leucine-rich repeat containing family receptors and their expression in channel catfish. Developmental Comparative Immunology. 33(9): 991-999. SCI一区

23)   Sha ZX, Xing SC, Shao CW, Tian YS, Liao XL., Chen SL. 2009. Isolation and characterization of 12 polymorphic microsatellite markers from ladyfish (Elops saurus Linnaeus). Conservation Genetics. 10(6): 1799-1801.

24)     Sha ZX, Xu P, Takano T, Liu H, Terhune J, Liu ZJ. 2008. The warm temperature acclimation protein Wap65 as an immune response gene: its duplicates are differentially regulated by temperature and bacterial infections. Molecular Immunology. 45(5): 1458-1469.

注:本人为第一作者、通讯或共同通讯作者论文

授权的国家发明专利:

1)      沙珍霞,陈亚东,曾艳,向晋松,路飏,陈松林,公光业,王天姿,邵长伟。2014 一种具有免疫效果的基因,ZL 20140249584.6

2)      沙珍霞,盛军,郑媛,纪晓峰,王致鹏。一种壳寡糖酶变构体,ZL 201610212888.4

3)      陈松林,叶寒青,沙珍霞。鱼类肌肉生长抑素MSTN基因克隆及其基因打靶载体构建,ZL200510104768.4

4)      陈松林,任国诚,沙珍霞。鱼类胚胎细胞分离与培养方法,ZL200510044628.2

5)      王娜,陈松林,王贤丽,沙珍霞。一种大菱鲆肾细胞系的构建方法及应用,ZL200910016926.9

6)      陈松林,张玉喜,刘云国,沙珍霞,田永胜,邓寒。牙鲆抗病相关MHC基因标记及其辅助育种方法,ZL200510045555.9

7)      陈松林,李静,田永胜,沙珍霞,王清印,庄志猛,徐建勇。半滑舌鳎雌性特异AFLP片段及遗传性别鉴定的PCR方法,ZL200610044177.7

8)      陈松林,邓思平,田永胜,沙珍霞,王清印。半滑舌鳎性逆转的诱导方法,ZL2006101710173

9)      陈松林,田永胜,徐田军,邓寒,沙珍霞,刘本伟,季相山,于过才。鱼类家系建立和抗病高产良种选育方法,ZL 200810138063.8

科研成果奖励:

1)      2014-2015年度农业部创新团队,2015,(等同于农业部成果一等奖,位2

2)      牙鲆快速生长良种培育技术的建立与应用,2014,山东省科学技术奖二等奖(位5

3)      牙鲆良种培育技术的建立及鲆优1新品种创制和应用,2013,青岛市科技进步一等奖(位4

4)      海水鲆鲽鱼类基因资源发掘与应用,2010,山东省科学技术奖二等奖(位3

5)      海水养殖鱼类遗传资源发掘与推广应用,2009,中华农业科技奖一等奖(位4

6)      龙须菜遗传特性的研究,2000,国家海洋局海洋科技进步一等奖(位5

7)      重要海水养殖鱼类精子和胚胎冷冻保存及种质冷冻库建立的研究,2005.1.11,海洋创新成果奖二等奖(位3

8)      海水养殖鱼类基因资源发掘、种质创制与应用,2009,海洋创新成果二等奖(位4

9)   重要海水养殖鱼类基因资源发掘、种质创新与应用,2009,首届中国水产学会范蠡科学技术奖一等奖(位6

10) 半滑舌鳎性染色体进化及性别分会和底栖适应机制研究,2015,中国水产科学研究院大渔创新奖(位5

11) 半滑舌鳎舌鳎性别特异分子标记及遗传性别鉴定技术的建立与应用,2009,中国水产科学研究院科技进步奖一等奖(位4

12) 重要海水养殖鱼类精子和胚胎冷冻保存及种质冷冻库建立的研究,2005,中国水产科学研究院科技进步二等奖(位3

 

联系方式:

E-mail: shazhenxia@163.com

 

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